Pall Allegro Recirculation Loop Manifold 10 L Sterile

Description

Pall Allegro iCELLis Nano Recirculation Loop Manifold System – 10 L, Single-Use, Sterile (MPN: 6415-1540G)

The Pall Allegro 6415-1540G (distributed under Cytiva) is a high-capacity, single-use recirculation loop manifold assembly precision-engineered for industrial scale upstream bioprocessing. Custom-configured explicitly to interface with the Pall iCELLis® Nano automated fixed-bed bioreactor system, this 10-liter scale manifold controls continuous process fluid loops during extensive adherent cell cultures. Constructed from premium, bio-inert USP Class VI polymers, this fluidics layout maintains media homogeneity, unhindered gas transport, and uniform nutrient delivery from large perfusion loops or baseline external media reservoirs. Supplied gamma-sterilized and fully consolidated, this single-use fluid path completely deletes the labor overhead, equipment downtime, and stringent verification parameters linked to legacy stainless steel Clean-in-Place (CIP) setups.

Technical Performance and Design

• iCELLis® Nano Fixed-Bed Integration: Custom-configured to connect flawlessly to the fluidics core of iCELLis Nano benchtop bioreactors, ensuring seamless continuous media routing and precise perfusion loop control during adherent cell expansions.

• Homogeneous Perfusion Dynamics: Engineered to manage an expanded 10 L process scale volume with optimized internal fluid dynamics. The smooth-bore single-use tubing design maintains consistent cross-flow velocities and eliminates “dead legs” where cellular aggregates or media can stagnate.

• Pre-Validated Closed System Architecture: Arrives fully integrated with high-purity, biopharmaceutical-grade tubing and secure, leak-proof connective components. This plug-and-play assembly virtually removes operator assembly errors and safeguards the master batch from external bio-contamination.

• Certified Single-Use Cleanliness: Manufactured inside ISO-certified cleanrooms, this manifold system is gamma-irradiated to strict sterility standards. It is thoroughly certified free of detectable endotoxins, particulates, and animal-derived components to shield delicate viral vectors or mammalian lines from analytical artifacts.

Product Specifications

• Catalog Number / MPN: 6415-1540G (64151540G)

• Manufacturer / Brand: Pall Corporation / Cytiva (Allegro™ Product Line)

• System Scale / Capacity: 10 Liters (10 L)

• Component Type: Single-Use Recirculation Loop Manifold

• Material Composition: High-Purity, USP Class VI Biocompatible Polymers

• Sterility Status: Pre-Sterilized via Gamma Irradiation

• Application Horizon: Upstream Perfusion and Recirculation Bioprocessing

Key Benefits & Applications

• Adherent Cell Culture Scale-Up: The premier industrial component for optimizing environmental conditions inside automated, fixed-bed single-use systems cultivating anchorage-dependent mammalian cell lines.

• Gene Therapy & Vaccine Production: Widely utilized in viral vector seed trains (such as AAV and Lentivirus), ensuring continuous nutrient supply and uniform oxygenation profiles over extended production run cycles.

• Bypassed Cleaning Validation: Shifting from a reusable fluid line to this single-use configuration completely clears the facility of multi-hour hot steam cycles and analytical cross-contamination testing protocols.

• Maximized Process Uptime: Allows upstream engineering teams to transition between separate experimental batches or cell runs in a fraction of the time simply by swapping out the disposable manifold core.

Expiration: 2024-05.

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