Description
Description
Nn-Diisopropylethylamine Reagentplus ≥99% 2.5 Liter
Synonym:‘Hünig’s base’, N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine
- CAS Number 7087-68-5
- Linear Formula [(CH3)2CH]2NC2H5
- Molecular Weight 129.24
- EC Number 230-392-0
- MDL number MFCD00008868
- PubChem Substance ID 329798682
- NACRES NA.21
| grade | ReagentPlus® |
| vapor pressure | 31 mmHg ( 37.7 °C) |
| assay | ≥99% |
| refractive index | n20/D 1.414 (lit.) |
| bp | 127 °C (lit.) |
| mp | <−50 °C (lit.) |
| density | 0.742 g/mL at 25 °C (lit.) |
| SMILES string | CCN(C(C)C)C(C)C |
| InChI | 1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3 |
| InChI key | JGFZNNIVVJXRND-UHFFFAOYSA-N |
General description
N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions. It acts as an activator for chiral iridium N, P ligand complexes, which can be utilized in the hydrogenation of α, β-unsaturated nitriles. The influence of varying concentration of N,N-diisopropylethylamine on the synthesis of olvanil in the presence of lipase catalyst has been investigated.
Application
N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.
Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.
GHS02, GHS05, GHS06
Signal word Danger
Hazard statements H225-H302-H318-H331-H335
Precautionary statements P210-P261-P280-P305 + P351 + P338-P311
RIDADR UN 3384 3(6.1) / PGI
WGK Germany 2
Flash Point(F) 53.6 °F
Flash Point(C) 12 °C
Documents
Safety Data Sheet
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